Founded in 1942, Monumental City Medical Society is the first African-American physician association in Baltimore. Prior to the formation of Monumental, African-American physicians had joined with African-American dentists and pharmacists to establish the Maryland Medical, Dental and Pharmaceutical Association (MMDPA) in 1905. However, because physicians had unique issues of licensure, hospital privileges and patient access, they developed Monumental as a distinct organization to address their needs. Monumental is also an affiliate of the National Medical Association.

Members of Monumental represent family practice, internal medicine, general and specialized surgery, obstetrics and gynecology, pediatrics, numerous subspecialties, psychiatry and physiatry. Monumental also has associate members consisting of physician assistants, rehab specialists (physical therapists, occupational therapists, speech therapists), nurses and medical students.

Monumental City Medical Society takes pride in being named the "1993-1994 Chapter of The Year" for the National Medical Association.